Which chemotherapeutic agents are used for palliation of metastatic carcinoid tumors?

Updated: Feb 12, 2019
  • Author: Cameron K Tebbi, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

Chemotherapeutic agents currently used in clinical trials to palliate metastatic carcinoid disease include the following:

  • Alkylating agents

  • Doxorubicin

  • 5-Fluorouracil

  • Dacarbazine

  • Actinomycin D

  • Cisplatin

  • Etoposide

  • Streptozotocin

  • Interferon alfa

  • Somatostatin analogs with a radioactive load

  • Experimental agents such as 177Lu-Dotatate

A combination of the agents listed above is typically used.

Chemoembolization of hepatic artery for treatment of metastatic carcinoid tumor has been widely used in adults. [83]

In one study, 8 adults with carcinoid tumor metastatic to liver were treated with intra-arterial 5-fluorouracil and embolization of hepatic tumors with bovine collagen fiber admixed with iohexol, cisplatin, mitomycin C, and doxorubicin. This treatment resulted in symptomatic relief and tumor regression in 4 patients and stabilized the disease in the rest of the patients.


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