Which medications in the drug class Antipyretics are used in the treatment of Pediatric Chickenpox?

Updated: Nov 30, 2018
  • Author: Kirsten A Bechtel, MD; Chief Editor: Russell W Steele, MD  more...
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These agents inhibit central synthesis and release of prostaglandins that mediate the effect of endogenous pyrogens in the hypothalamus; thus, they promote the return of the set-point temperature to normal.

The fever is usually low grade but may be elevated. Acetaminophen is probably the safest drug to use for this purpose. Salicylate usage for varicella is associated with Reye syndrome; therefore, never prescribe these agents. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been suspected of suppressing immune function and promoting infection progress in patients infected with invasive group A streptococci.

Acetaminophen (Tylenol, Feverall, Tempra, Aspirin-Free Anacin)

Acetaminophen is the drug of choice because it has no association with Reye syndrome. It is available as drops containing 80 mg/0.8 mL; a suspension containing 160 mg/5 mL; a chewable tablet or capsule containing 80 mg; and a tablet containing 160 mg, 325 mg, or 500 mg.

Ibuprofen (Motrin, Ibuprin)

Ibuprofen A is a propionic acid–derivative NSAID. It acts by inhibiting prostaglandin synthesis and also has anti-inflammatory and analgesic properties. It is available as an oral suspension (100 mg/5 mL) and a tab containing 200 mg, 400 mg, 600 mg, or 800 mg.

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