How are coronary microvascular lesions characterized in Kawasaki disease?

Updated: Jul 29, 2018
  • Author: Tina K Sosa, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Upon ultrastructural examination, myocardial changes reveal hypertrophy, various degrees of degeneration, proliferation and abnormality of mitochondria, infiltration of a small number of lymphocytes, and fibrosis. Coronary microvascular lesions are characterized by the following:

  • Microvascular dilatation

  • Endothelial cell injury

  • Platelet aggregation with thrombosis

  • Stenotic lumen with thickened walls in the small arterioles [68]


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