What are the risk factors for coronary artery aneurysm (CAA) in Kawasaki disease?

Updated: Jul 29, 2018
  • Author: Tina K Sosa, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Risk factors for CAAs include the following:

  • Fever >8 days

  • Recurrence of fever after an afebrile period of at least 48 hours

  • Male sex

  • Cardiomegaly

  • Age younger than 1 year

  • Asian and Pacific Islander race

  • Hispanic ethnicity

The most important predictor is total duration of fever longer than 8 days. [50] Incomplete Kawasaki disease may also be an independent predictor of CAA development. [51] Wilder et al reported that delayed diagnosis contributes to the development of these aneurysms. [52]  Studies have shown that even in children who do not form aneurysms, up to 50% show a decrease in ventricular function and/or mild valvular regurgitation on echocardiograms.


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