How is microscopy used to determine the etiology of Kawasaki disease?

Updated: Jul 29, 2018
  • Author: Tina K Sosa, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Using light and electron microscopy, researchers have identified cytoplasmic inclusion bodies containing RNA in 85% of acute- and late-stage KD fatalities and 25% of adult controls. Based on this finding, it is hypothesized that the KD infective agent could be a ubiquitous RNA virus that results in asymptomatic infection in most individuals, but leads to KD in a subset of genetically predisposed individuals. It is also possible that many infectious agents trigger one final common pathway in susceptible hosts, which leads to KD. [1]


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