What is the role of cerebrospinal fluid (CSF) analysis in the evaluation of herpes simplex virus (HSV)?

Updated: Feb 27, 2019
  • Author: J Michael Klatte, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Evaluation of cerebrospinal fluid (CSF) specimens from patients with biopsy-proven herpes simplex virus encephalitis and in those with other proven diseases has a sensitivity of greater than 95% and a specificity that approaches 100% at the time of clinical presentation. Overall sensitivities of PCR in neonatal herpes simplex virus disease range from 75-100%, with overall specificities of 71-100%. [10]


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