What are the signs and symptoms of herpes simplex virus (HSV) infection of the CNS?

Updated: Feb 27, 2019
  • Author: J Michael Klatte, MD; Chief Editor: Russell W Steele, MD  more...
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Clinical features of HSV CNS infection may include the following:

  • Insidious or abrupt onset

  • Headache, altered consciousness, and focal neurologic abnormalities at presentation

  • Symptoms of aseptic meningitis (headache, fever, stiff neck, photophobia)

  • Symptoms of autonomic nervous system dysfunction and transverse myelitis (eg, hyperesthesia or anesthesia of the lower back, perineum, or sacral region)

See Clinical Presentation for more detail.

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