What are the signs and symptoms of orolabial herpes simplex virus (HSV) infection?

Updated: Feb 27, 2019
  • Author: J Michael Klatte, MD; Chief Editor: Russell W Steele, MD  more...
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Clinical features of orolabial HSV infection include the following [1] :

  • Abrupt onset of illness

  • Fever

  • Listlessness or irritability

  • Inability to eat and/or drink

  • Gingivitis (with markedly swollen, erythematous, and occasionally bleeding gums)

  • Increased drooling in infants due to pain on swallowing

  • Vesicular lesions on the tongue, buccal mucosa, and palate with extension, at times, to the lips and face (these may rupture and coalesce to form large, ulcerated areas)

  • Tender submandibular or cervical adenopathy

  • In recurrent cases, a prodrome of pain, burning, tingling, and itching

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