What is the efficacy of the Shanchol cholera vaccines?

Updated: Feb 03, 2021
  • Author: Sajeev Handa, MBBCh, BAO, LRCSI, LRCPI; Chief Editor: Russell W Steele, MD  more...
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Answer

A study by Qadri et al assessed the feasibility and protective effect of delivering the vaccine Shanchol through routine government services in urban Bangladesh and evaluated the benefit of adding behavioral interventions to encourage safe drinking water and hand washing along with the vaccination.  The study analyzed 267,270 people, 94,675 assigned to vaccination only, 92,539 assigned to vaccination and behavioral change, and 80,056 assigned to non-intervention. The study found that vaccine coverage was 65% in the vaccination only group and 66% in the vaccination and behavioral change group. Overall protective effectiveness was 37% in the vaccination group and 45% in the vaccination and behavioral change group. [28, 29]

A study by Matias et al found that immunization with the bivalent oral cholera vaccine (Shanchol) induced antibody secreting cell responses among a cohort of healthy adults in Haiti after a single dose, however, the second dose of vaccine resulted in a minimal response. [30]


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