What are the types of cholera vaccines?

Updated: Feb 03, 2021
  • Author: Sajeev Handa, MBBCh, BAO, LRCSI, LRCPI; Chief Editor: Russell W Steele, MD  more...
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Answer

Shanchol and ORCVAX are bivalent vaccines that are based on serogroups O1 and O139; however, they do not contain the bacterial toxin B subunit. ORCVAX was originally formulated in Vietnam in 1997 and was modified in 2004. Over 20 million doses have been administered to adults and children in endemic areas of Vietnam. Shanchol is a similar formulation available in India. Shanchol is administered in 2 liquid doses 14 days apart in adults and children older than 1 year. A booster dose is recommended after 2 years. [18]

CVD 103-HgR is a cholera vaccine developed by the Swiss Serum and Vaccine Institute in Berne, Switzerland. This vaccine, although not recognized by the WHO, is available in Europe, Latin America, and, since 1997, Canada. The vaccine is composed of attenuated V cholerae O1 prepared by recombinant DNA. It has been tested in industrialized countries and in developing countries that have endemic, epidemic, and little or no cholera. [19]


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