What is the role of cyclic adenosine monophosphate (cAMP) in the pathogenesis of cholera?

Updated: Feb 03, 2021
  • Author: Sajeev Handa, MBBCh, BAO, LRCSI, LRCPI; Chief Editor: Russell W Steele, MD  more...
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Answer

The A1 subunit of cholera toxin activates adenylate cyclase to cause a net increase in cyclic adenosine monophosphate (cAMP). The increased cAMP then carries on the downstream effects. cAMP blocks the absorption of sodium and chloride by the microvilli and promotes the secretion of chloride and water by the crypt cells. [3, 4] The result is watery diarrhea with electrolyte concentrations isotonic to those of plasma.


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