What should be included in the differential diagnoses for generalized lymphadenitis?

Updated: Feb 12, 2019
  • Author: Elizabeth Partridge, MD, MPH, MS; Chief Editor: Russell W Steele, MD  more...
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Generalized lymphadenitis

In a patient with generalized lymphadenitis, the differential includes systemic conditions.

Associated medication toxicities are as follows:

  • Hydralazine

  • Allopurinol

Associated infections are as follows:

  • Epstein-Barr virus infection

  • Cytomegalovirus infection

  • Toxoplasmosis

  • HIV disease

  • Tuberculosis (advanced)

  • Histoplasmosis

  • Coccidioidomycosis

  • Brucellosis

  • Bacterial endocarditis

  • Hepatitis

  • Syphilis (secondary)

Associated immunologic diseases are as follows:

  • Sarcoidosis

  • Rheumatoid arthritis

  • Lupus

Associated malignancies are as follows:

  • Acute lymphoblastic leukemia

  • Chronic lymphocytic leukemia

  • Lymphomas

  • Angiofollicular lymph node hyperplasia (Castleman disease)

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