What is the role of prophylaxis in the treatment of pediatric factor XIII (FXIII) deficiency?

Updated: Jun 28, 2021
  • Author: Helge Dirk Hartung, MD; Chief Editor: Cameron K Tebbi, MD  more...
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For patients with homozygous factor XIII deficiency, prophylaxis is the best approach. [14]

  • Individuals who require plasma-derived factor XIII concentrate should be immunized with hepatitis A and hepatitis B vaccines.

  • Aspirin and other drugs that impair platelet function should be avoided.

  • Women at risk for spontaneous abortion should be evaluated for the need of enhanced prophylaxis starting in early pregnancy.

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