How is polyostotic sclerosing histiocytosis treated?

Updated: Sep 16, 2020
  • Author: Cameron K Tebbi, MD; Chief Editor: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP  more...
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Answer

Treatment for polyostotic sclerosing histiocytosis includes the following:

  • Steroid therapy
  • Interferon alpha (regular or PEGylated)
  • Interleuken-1 receptor antagonists
  • Chemotherapy - Vinblastine, vincristine, cyclophosphamide, tyrosine kinase inhibitors, doxorubicin, cladribine, methotrexate, imatinib, tamoxifen, azathioprine, mycophenolate mofetil
  • Radiation therapy
  • Bisphosphonates
  • Vemurafenib [192]
  • Surgery
  • Transplantation with autologous hemopoietic stem cells

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