Which age groups have the highest prevalence of Langerhans cell histiocytosis (LCH)?

Updated: Sep 16, 2020
  • Author: Cameron K Tebbi, MD; Chief Editor: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP  more...
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LCH can occur in individuals of any age. [48, 51, 52, 53, 54, 55, 56, 57] The incidence peaks in children aged 1-3 years. In one study, the age at diagnosis was 0.09-15.1 years. Patients with single system involvement were older than those with multisystem involvement. The mean age for development of polycystic sclerosing histiocytosis is between 55 and 60 years, but rare cases in the pediatric age group have been reported. Fetal and neonatal cases, although also rare, can occur. [48, 58]

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