What is the prognosis of polyostotic sclerosing histiocytosis?

Updated: Sep 16, 2020
  • Author: Cameron K Tebbi, MD; Chief Editor: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP  more...
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Polyostotic sclerosing histiocytosis

Negative prognostic factors in polyostotic sclerosing histiocytosis include central nervous system (CNS) involvement, cardiovascular disease, and the use of interferon alpha. [49]

The 1- and 5-year survival rates in this disease are 96% and 68%, respectively. Causes of death include the following:

  • CNS involvement
  • Cerebral hypertension
  • Myocardial infarction
  • Gastrointestinal bleed
  • Pulmonary infections
  • Metabolic abnormalities

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