What is the mortality and morbidity associated with hypoprothrombinemia?

Updated: Jun 16, 2021
  • Author: J Nathan Hagstrom, MD; Chief Editor: Cameron K Tebbi, MD  more...
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In both acquired and inherited hypoprothrombinemia, the morbidity and mortality risks are related to the circulating level of factor II. The risks are less than 2% with severe deficiency, 2-10% with moderate deficiency, and 10-40% for mild deficiency.

In a prothrombin knockout-mouse model, complete prothrombin deficiency led to a 50% mortality rate on embryonic day 10.5. [3] Some embryos survive to birth but die from hemorrhaging on the first day. In humans, severe life-threatening hemorrhage, including intracranial hemorrhage, is described in neonates with severe prothrombin deficiency. Severe prothrombin deficiency is likely to lead to spontaneous abortion and fetal demise in some cases. Complete prothrombin deficiency in humans has not been reported; this omission suggests that this condition is incompatible with life.

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