What are the screening recommendations for families with hereditary breast cancer?

Updated: May 03, 2021
  • Author: Harsh Grewal, MD, FACS, FAAP; Chief Editor: Robert K Minkes, MD, PhD  more...
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Screening recommendations for families with hereditary breast cancer (ie, BRCA1, BRCA2, Li-Fraumeni) include examination by a physician twice a year. Screening mammography should be performed once or twice yearly, beginning when the patient is aged 10 years younger than the youngest affected relative or no older than age 35 years.

Patients who have positive test findings for the BRCA1 or BRCA2 genes may opt to undergo prophylactic bilateral mastectomy, which is associated with an approximately 90% reduction in the risk of breast cancer. [38] Depending on the age at diagnosis in the first-degree relative, prophylactic mastectomies may be delayed until age 35 years or until childbearing is complete. [32]

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