Which medications in the drug class Antidepressants, TCAs are used in the treatment of Cyclic Vomiting Syndrome?

Updated: Oct 31, 2018
  • Author: Thangam Venkatesan, MD; Chief Editor: Carmen Cuffari, MD  more...
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Antidepressants, TCAs

Tricyclic antidepressants are a complex group of drugs that have central and peripheral anticholinergic effects, as well as sedative effects. They may block the active reuptake of norepinephrine and serotonin.


Tricyclic antidepressants (TCAs) such as amitriptyline are excellent first-line choices in children older than 5 years. Amitriptyline has anticholinergic and sedating side effects and thus is best administered at bedtime. Cardiac arrhythmia, especially in overdose, has been described; monitoring the QTc interval both before therapy is initiated and after the target level has been reached is advised. Up to 1 month may be needed for clinical effects to become evident.

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