Which medications in the drug class Beta-Adrenergic Blocking Agents are used in the treatment of Cyclic Vomiting Syndrome?

Updated: Oct 31, 2018
  • Author: Thangam Venkatesan, MD; Chief Editor: Carmen Cuffari, MD  more...
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Beta-Adrenergic Blocking Agents

Beta-blockers may reduce the frequency and severity of episodes. Propranolol is usually recommended because of its CNS penetration.

Propranolol (Inderal LA, InnoPran XL)

Propranolol is a beta-adrenergic blocker and an excellent first-line agent for prophylaxis when used at low doses. It has a 57% efficacy rate, with efficacy defined as a 50% reduction in the frequency and severity of episodes. It requires 1 week for efficacy and requires gradual withdrawal over 1 week. Dosing may be monitored on the basis of a fall in presleep resting pulse from baseline; a decline of less than 15-20 beats/min indicates that the dose may be further increased.

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