Which medications in the drug class Anticonvulsants are used in the treatment of Cyclic Vomiting Syndrome?

Updated: Oct 31, 2018
  • Author: Thangam Venkatesan, MD; Chief Editor: Carmen Cuffari, MD  more...
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Agents that inhibit brain glutamate decarboxylase, which causes a decrease in the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), may help reduce the frequency and severity of episodes.


Phenobarbital may be used in patients with or without electroencephalographic (EEG) changes. A 79% response rate has been observed in patients with CVS.

Topiramate (Topamax)

Topiramate is a sulfamate-substituted monosaccharide with a broad spectrum of antiepileptic activity; it may have state-dependent sodium channel blocking action. It potentiates the inhibitory activity of the neurotransmitter GABA. In addition, topiramate may block glutamate activity and, in turn, help reduce the frequency and severity of episodes.

Zonisamide (Zonegran)

Zonegran blocks T-type calcium channels, prolongs sodium channel inactivation, and is a carbonic anhydrase inhibitor.

Levetiracetam (Keppra, Keppra XR)

Levetiracetam may facilitate GABAergic inhibitory transmission through displacement of negative modulators.

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