What is the pathophysiology of irritable bowel syndrome (IBS)?

Updated: Dec 30, 2019
  • Author: Mohammad F El-Baba, MD; Chief Editor: Carmen Cuffari, MD  more...
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As yet, irritable bowel syndrome (IBS) has no identifiable pathophysiologic mechanism, and laboratory testing is unrevealing. [1, 3] Over the last several decades, the understanding of irritable bowel syndrome has evolved from a disorder of motor activities in the upper and lower gastrointestinal (GI) tracts to a more integrated understanding of visceral hypersensitivity and brain-gut interaction.

More recently, non-immunoglobulin E (non-IgE) wheat allergy and overlap of non-celiac gluten sensitivity (NCGS) with irritable bowel syndrome-type symptoms has been recognized. [4]

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