Which antimicrobial agents are used in the treatment of diarrhea?

Updated: Jan 31, 2020
  • Author: Stefano Guandalini, MD; Chief Editor: Carmen Cuffari, MD  more...
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In terms of recommended antimicrobial treatment in the immunocompetent host, enteric bacterial and protozoan pathogens can be grouped as follows:

Agents for whom antimicrobial therapy is always indicated: The consensus includes only V cholerae, Shigella species, and G lamblia.

Agents for whom antimi­crobial therapy is indicated only in selected circumstances, include the following:

  • Infections by enteropathogenic E coli, when running a prolonged course

  • Enteroinvasive E coli, based on the sero­logic, genetic, and pathogenic similarities with Shigella

  • Yersinia infections in subjects with sickle cell disease

  • Salmonella infections in very young infants, if febrile or with positive blood culture findings

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