Which medications in the drug class Vaccines, Inactivated, Bacterial are used in the treatment of Frostbite?

Updated: Oct 13, 2020
  • Author: Bobak Zonnoor , MD; Chief Editor: Dirk M Elston, MD  more...
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Vaccines, Inactivated, Bacterial

Toxoids are used for tetanus immunization in patients at risk of frostbite-associated tetanus. Booster injection in previously immunized individuals is recommended to prevent this potentially lethal syndrome. In a patient who was never fully immunized, these should be supplemented with tetanus immune globulin 250 U intramuscularly (IM).

Diphtheria and tetanus toxoids (Decavac)

Tetanus and diphtheria toxoids are used to induce active immunity against tetanus in selected patients. They are the immunizing agents of choice for most adults and children older than 7 years. Booster doses must be administered to maintain tetanus immunity throughout life. Pregnant patients should receive only tetanus toxoid, not a diphtheria antigen-containing product.

In children and adults, tetanus and diphtheria toxoids may be administered into the deltoid or the midlateral thigh muscles. In infants, the preferred site of administration is the mid thigh laterally.

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