Which clinical history findings are characteristic of microphallus?

Updated: Nov 30, 2020
  • Author: Karen S Vogt, MD; Chief Editor: Sasigarn A Bowden, MD  more...
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Neonatal hypoglycemia is associated with other pituitary hormone deficiencies, including panhypopituitarism, growth hormone deficiency, and adrenal insufficiency. Other features that may be associated with hypopituitarism during the neonatal period include breech delivery, optic nerve hypoplasia or aplasia, nystagmus, other midline defects, and cholestasis with prolonged direct hyperbilirubinemia.

Poor growth or failure to thrive is also associated with other pituitary hormone deficiencies.

An abnormal sense of smell (anosmia or hyposmia) suggests Kallmann syndrome (hypogonadotropic hypogonadism with abnormal olfaction).

Other congenital anomalies may provide clues to a genetic syndrome.

Family history of similarly affected children could suggest a familial form of hypogonadism or other hormone deficiency, defect in steroidogenesis (autosomal recessive), or androgen insensitivity (X-linked). Family history of unexplained death in the first year of life could suggest pituitary hormone deficiencies, adrenal insufficiency, or both.

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