What are the possible complications of growth hormone receptor deficiency (GHRD)?

Updated: Jan 15, 2019
  • Author: Arlan L Rosenbloom, MD; Chief Editor: Robert P Hoffman, MD  more...
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Answer

Cardiovascular risk may be increased in GHRD, similar to that seen with GH deficiency in adults, and associated with increased total and LDL cholesterol levels.

While pregnancy is uncomplicated in GHRD, delivery requires cesarean delivery.

Infants, toddlers, and preschool children with GHRD appear to be at greater risk of death from prevalent infections than unaffected siblings.

Obesity, particularly in females, becomes a serious problem with aging but has not been associated with insulin resistance, diabetes, or increased cancer risk, as is seen in unaffected populations and unaffected relatives. [33]


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