Which medical conditions and treatments may have negative interactions with medications used to manage attention deficit hyperactivity disorder (ADHD)?

Updated: Sep 09, 2021
  • Author: Maggie A Wilkes, MD; Chief Editor: Caroly Pataki, MD  more...
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Screening for medical concerns that may have negative interactions with ADHD (ADD) medications (Drugs of concern are shown in parentheses.)

  • Major arterial disease (stimulants)

  • Narrow-angle glaucoma (stimulants, imipramine, desipramine)

  • Heart disease (clonidine, desipramine, guanfacine, imipramine, stimulants)

  • Heart palpitations (stimulants)

  • Hepatic disease (atomoxetine)

  • Hypertension (stimulants, atomoxetine, bupropion)

  • Orthostasis (atomoxetine, bupropion, stimulants)

  • Pregnancy (all)

  • Renal disease (bupropion, clonidine)

  • Seizure disorder (bupropion, desipramine, imipramine)

  • Urinary retention or hesitancy (atomoxetine, bupropion, stimulants)

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