Which medications in the drug class Topical Skin Products are used in the treatment of Pediatric Keratosis Pilaris?

Updated: May 27, 2021
  • Author: Derek H Chu, MD; Chief Editor: Dirk M Elston, MD  more...
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Topical Skin Products

Alpha hydroxy acid is a normal constituent of tissues and blood. Acids act as humectants when applied topically and may decrease corneocyte cohesion.

Topically applied urea has a hygroscopic effect by increasing the water retention in skin. This helps to reduce pruritus.

Salicylic agents produce desquamation of the skin's horny layer. They are keratolytic at concentrations of 2-6%.

Salicylic acid topical (Clean & Clear Advantage, Neutrogena Acne Stress Control, Neutrogena Oil Free)

Salicylic acid topical removes excess keratin.

Ammonium lactate (Lac-Hydrin, AmLactin, Geri-Hydrolac 12)

Ammonium lactate is an emollient available in 225- and 400-g bottles and promotes hydration and removal of excess keratin. It contains lactic acid, an alpha-hydroxy acid that has keratolytic action, thus facilitating the release of comedones.

Urea cream 20% (Carmol 20, Ureacin 20, Gormel, DPM, Uramaxin)

Application of 20% urea promotes hydration and the removal of excess keratin.

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