What is the role of biopsy in the workup of pediatric aphthous ulcers?

Updated: Feb 25, 2019
  • Author: Michael C Plewa, MD; Chief Editor: Russell W Steele, MD  more...
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  • Histopathologic examination of biopsy specimens does not reveal unique findings and is rarely indicated, except to exclude other diagnoses, such as pemphigus, cicatricial pemphigoid, carcinoma, and Behçet disease.

  • Persistent ulceration in a patient with human immunodeficiency virus (HIV) should be biopsied to exclude carcinoma. [31]

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