What is the role of extracorporeal membrane oxygenation (ECMO) in the treatment of persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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ECMO, an adaptation of cardiopulmonary bypass, is used when aggressive medication and ventilatory support fails to maintain acceptable oxygenation and perfusion. [2, 3]

The most common indications for ECMO use among neonates in the United States are meconium aspiration syndrome and congenital diaphragmatic hernia. An analysis of the Extracorporeal Life Support Organization (ELSO) registry from 1999-2004 reported that neonates with PPHN represented more than 20% of those requiring ECMO support. [35]

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