What is included in the differential diagnoses of persistent pulmonary hypertension of the newborn (PPHN)?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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The differential diagnosis for persistent pulmonary hypertension of the newborn (PPHN) includes the following*:

  • Cyanotic congenital heart disease, such as transposition of the great arteries, [29] obstructed total anomalous pulmonary venous connection, tricuspid atresia, and pulmonary atresia with intact ventricular septum

  • Primary parenchymal lung disease such as neonatal pneumonia, respiratory distress syndrome, pulmonary sequestration, and pulmonary hypoplasia resulting in hypercarbia and respiratory acidosis

  • Sepsis

  • Alveolar capillary dysplasia

  • Surfactant protein B deficiency

  • Respiratory or metabolic acidosis of any etiology

  • Meconium aspiration syndrome

  • Asphyxia

*PPHN can occur in isolation or as a result of any of the above diagnoses, with the exception of structural heart lesions.

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