What is the incidence of persistent pulmonary hypertension of the newborn (PPHN) in the US?

Updated: Sep 03, 2019
  • Author: Kate A Tauber, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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The incidence of persistent pulmonary hypertension in the newborn (PPHN) in the United States has been reported to range from 0.4 to 6.8 per 1000 live births. [4]  Although PPHN has been traditionally thought of as a diagnosis in term newborns, it is increasingly being recognized in preterm infants. One study reported an incidence of 5.4 per 1000 live births in infants 34-36 weeks' gestation. [24]

An analysis of the North American Pediatric Pulmonary Hypertension Network Registry (2014-2018) found "significant racial variability in the prevalence of pulmonary hypertension subtypes and survival outcomes among children with pulmonary hypertension." [25] For example, black neonates had a higher prevalence of PPHN and an increased mortality risk, whereas white neonates had a greater prevalence of congenital diaphragmatic hernia. [25]

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