Which medications in the drug class Antivirals, Other are used in the treatment of Pediatric Severe Combined Immunodeficiency?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Harumi Jyonouchi, MD  more...
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Antivirals, Other

HSV, CMV, and VZV are treated with acyclovir. Oral absorption is poor; thus, most patients require IV administration. Ganciclovir is an alternative drug, also administered IV, for the same viral infections. Both drugs are used for prophylaxis after exposure to VZV beyond the 72- to 96-hour period within which varicella zoster immune globulin (VZIG) is effective at 50% of the therapeutic dose.

Acyclovir (Zovirax)

Acyclovir is given in a high dose of 45-60 mg/kg/day or 1500 mg/m2/day divided every 8 hours for central nervous system (CNS) infection. Good hydration is essential, and lower doses must be calculated in the presence of renal compromise.

Ganciclovir (Cytovene)

Ganciclovir is the drug of choice for CMV infection and is used for HSV and VZV infections that are resistant to acyclovir.

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