Which specialist consultations are beneficial to patients with severe combined immunodeficiency (SCID)?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Harumi Jyonouchi, MD  more...
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Management of SCID required the participation of a number of different specialists, and coordinating their efforts can be challenging.

The need for excellent laboratory and radiology support mandates hospitalization in tertiary pediatric medical centers. Laboratory studies for stem cell reconstitution must be initiated promptly with the BMT team. In the meantime, gastroenterology and nutrition consultations provide important support.

As with any primary immunodeficiency disease, subtle signs of infection, morbidity/mortality from common infections, and the need to offer stem cell transplantation reinforces the importance of frequent monitoring and management by a clinical immunologist.

Consultation with an internal medicine specialist and an infectious disease specialist is important in the management and prevention of infection.

BMT should be coordinated between immunology/hematology and the BMT team. Admit the patient to an immunology/hematology clinic for IVIg therapy, IL-2 infusion, or PEG-ADA therapy, as necessary.

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