What are the racial predilections of severe combined immunodeficiency (SCID)?

Updated: Apr 28, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Harumi Jyonouchi, MD  more...
  • Print

No racial predisposition exists for most forms of SCID, but most patients with ZAP-70 deficiency and CD3δ are Mennonites. The Artemis gene deficiency is seen predominately in Navajo and Apache Native Americans. JAK3 mutations have been reported more frequently in Italy. MHC II deficiency is usually reported in North African individuals. RAG1/RAG2 -deficient SCID occurs more commonly in Europe. Cartilage-hair hypoplasia affects a Finnish population and the old Amish order in the United States.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!