Which histologic findings are characteristic of mold-related allergic asthma?

Updated: Dec 02, 2020
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Hyperinflation and airway plugging with exudate and mucus, especially in the bronchioles, can be seen postmortem.

Eosinophil infiltration is present in submucosa, and creola bodies are present. Surface epithelium shows significant disruption or loss.

The reticular basement membrane is homogeneously thickened with hyaline deposition. Smooth muscle in the larger airways is hypertrophied.

Edematous tissue is always present.

Bronchial glands are also enlarged.

Cellular infiltration is prominent with mononuclear cells positive for CD3, CD4, CD25, and IL-2 receptor (IL-2R), as well as many degranulated (activated) eosinophils.

Mast cells are notably increased in tissues.

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