Which pathogen-derived products may be therapeutic for mold allergy?

Updated: Dec 02, 2020
  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD  more...
  • Print

Several pathogen-derived products have been shown to possess therapeutic potentials for allergic diseases. It has been suggested the glucan of the wall component of a variety of fungi may have that potential. Kawashima et al, using an animal study, examined the effect of curdlan, a linear beta-(1-3)-glucan, on the development of allergic airway inflammation. [9] They found that an injection of curdlan significantly inhibited Ag-induced eosinophilic recruitment and Th2 cytokine productions in the airways. They found that STAT6-aided IL-10 production by CD4+ T cells in the presence of curdlan contributed to this process. It underscores the therapeutic potential of curdlan for various fungus-related allergic diseases.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!