Which medications in the drug class Antiviral Agents are used in the treatment of Cartilage-Hair Hypoplasia?

Updated: Aug 06, 2019
  • Author: Alan P Knutsen, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Antiviral Agents

Nucleoside analogs are initially phosphorylated by viral thymidine kinase (TK) to eventually form a nucleoside triphosphate.

Acyclovir (Zovirax)

Synthetic purine nucleoside analogue that inhibits herpes virus replication. Herpes virus TK, but not host cell TK, uses acyclovir as a purine nucleoside, converting it into acyclovir monophosphate, a nucleotide analogue. Guanylate kinase converts the monophosphate form into diphosphate and triphosphate analogues that inhibit viral DNA replication.

Valacyclovir (Valtrex)

Valacyclovir is metabolized to acyclovir and L-valine with better oral absorption than acyclovir.


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