What are the sexual predilections of agammaglobulinemia (hypogammaglobulinemia)?

Updated: Jul 08, 2019
  • Author: Donald A Person, MD, FAAP, FACR; Chief Editor: Harumi Jyonouchi, MD  more...
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Answer

Agammaglobulinemia can be either X-linked (XLA) or autosomal recessive. XLA is more often recognized as Bruton agammaglobulinemia. In a large European study involving 46 centers in 18 countries, hypogammaglobulinemia was the most common primary immunodeficiency disease (excluding agammaglobulinemia). Males accounted for 63% of this group of 2076 children. [18]


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