How are hyperplastic solitary thyroid nodules differentiated from colloid goiters?

Updated: Aug 19, 2020
  • Author: Daniel J Kelley, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Hyperplastic nodules can be differentiated from colloid goiters by the presence of excessive cellularity, acinar formation, marginal vacuoles, papillary formation, and the amount of colloid present in the specimen. Neoplasms have a higher degree of papillary formation, intranuclear inclusions and nuclear grooves, and fewer marginal vacuoles. Congenital thyroid nodules include congenital hemangioma, thyroglossal duct anomalies, and familial disorders, such as multiple endocrine neoplasia (MEN) syndromes and congenital goitrous hypothyroidism.

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