What is the role of lumbar puncture in the workup of cocaine toxicity?

Updated: Dec 31, 2020
  • Author: Lynn Barkley Burnett, MD, EdD, JD; Chief Editor: Sage W Wiener, MD  more...
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Renzi recommends lumbar puncture (LP) to rule out intracranial hemorrhage in patients with persistent headache after the patient's BP is normalized and contraindications are ruled out on head CT. [45] When LP is considered for this possible indication, remember that headaches are common in cocaine users secondary to decreased uptake of serotonin. Consider LP in all patients with hyperthermia or altered mental status.

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