What is the clinical presentation of phase III (depression and premorbid) cocaine toxicity?

Updated: Dec 31, 2020
  • Author: Lynn Barkley Burnett, MD, EdD, JD; Chief Editor: Sage W Wiener, MD  more...
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Phase III (depression and premorbid state) is as follows:

  • CNS - Coma, areflexia, pupils fixed and dilated, flaccid paralysis, and loss of vital support functions

  • Circulatory - Circulatory failure and cardiac arrest (VF or asystole)

  • Respiratory - Respiratory failure, gross pulmonary edema, cyanosis, agonal respirations, and paralysis of respiration

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