Supportive care, rather than specific antidotes, is the mainstay of management following caustic ingestions. Medications useful for this purpose include antibiotics, proton pump inhibitors, and analgesics. A systematic review and meta-analysis by Katibe et al concluded that the available evidence does not support the use of corticosteroids for the prevention of esophageal strictures following caustic ingestion, but noted that the overall quality of the evidence is limited. [22]
A significant exception to this would be the aggressive administration of intravenous calcium for dysrhythmias precipitated by hypocalcemia from hydrogen fluoride ingestion. Such therapy is best performed with the guidance of the toxicologist at the local poison center.
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Caustic ingestions. Endoscopic view of the esophagus in a patient who ingested hydrochloric acid (Lime-a-way). Note the extensive thrombosis of the esophageal submucosal vessels giving the appearance similar to chicken wire. Courtesy of Ferdinando L. Mirarchi, DO, Fred P. Harchelroad Jr, MD, Sangeeta Gulati, MD, and George J. Brodmerkel Jr, MD.
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Caustic ingestions. Endoscopic view of the esophagus in a patient who ingested hydrochloric acid (Lime-a-way). Note the appearance of the thrombosed esophageal submucosal vessels giving the appearance of chicken wire. Courtesy of Ferdinando L. Mirarchi, DO, Fred P. Harchelroad Jr, MD, Sangeeta Gulati, MD, and George J. Brodmerkel Jr, MD.
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Caustic ingestions. Endoscopic view of the esophagus in a patient who ingested hydrochloric acid (Lime-a-way). Note the extensive burn and thrombosis of the submucosal esophageal vessels, which gives the appearance of chicken wire. Courtesy of Ferdinando L. Mirarchi, DO, Fred P. Harchelroad Jr, MD, Sangeeta Gulati, MD, and George J. Brodmerkel Jr, MD.
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Algorithm for the diagnosis and management of caustic ingestions. In all cases of caustic ingestion, the airway should be assessed initially and protected if necessary. If endoscopy is not rapidly available and severe injury is strongly suspected, obtain a contrast-enhanced computed tomographic (CT) study. The Usta protocol consists of methylprednisolone (1 g per 1.73 m2 of body-surface area per day, given intravenously for 3 days) plus ranitidine (4 mg per kilogram of body weight per day in children or the standard adult dose in adults, given intravenously) plus ceftriaxone (100 mg per kilogram per day in children or the standard adult dose in adults, given intravenously). NPO denotes nothing by mouth, and TPN total parenteral nutrition.
