What is the efficacy of internal cooling methods in targeted temperature management (TTM)?

Updated: Jul 26, 2019
  • Author: Alex Koyfman, MD; Chief Editor: Karlheinz Peter, MD, PhD  more...
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Many have studied the effect of cold fluid infusion for the induction of mild-to-moderate hypothermia in humans. The rates of induction are variable but otherwise considered to be rapid. Cold fluid infusion with concomitant use of cooling blankets has also been shown to be efficacious. Typical infusion volume is either 30 mL/kg or 2 L of fluid using either normal saline or lactated Ringer solution. In the several studies that have investigated cold fluid infusion, there has not been an association with increased venous pressure, left atrial filling pressures, pulmonary pressures, pulmonary edema, cardiac arrhythmia, or other major complications. [35, 47, 49, 50, 51, 52, 53]

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