What are the inclusion criteria for targeted temperature management (TTM)?

Updated: Jul 26, 2019
  • Author: Alex Koyfman, MD; Chief Editor: Karlheinz Peter, MD, PhD  more...
  • Print


Patients who have been shown to benefit from induced hypothermia include the following; however, strict inclusion criteria vary by institution:

  • Intubated patients with treatment initiated within a 6-hour post cardiac arrest (nonperfusing ventricular tachycardia [VT] or ventricular fibrillation [VF]) time window

  • Patients able to maintain a systolic blood pressure above 90 mm Hg, with or without pressors, after cardiopulmonary resuscitation (CPR) [2, 3, 4] (This recommendation is primarily based on ensuring adequate end organ perfusion, as hypotension is associated with poor outcomes post arrest. Thus, clinicians should target adequate perfusion when beginning TTM.)

  • Those in a coma at the time of cooling. Coma is defined as not following commands. Brainstem reflexes and pathological/posturing movements are permissible. Patients with a Glasgow Coma Score (GCS) of 3 are eligible for hypothermia.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!