Which conditions may benefit from treatment with targeted temperature management (TTM)?

Updated: Jul 26, 2019
  • Author: Alex Koyfman, MD; Chief Editor: Karlheinz Peter, MD, PhD  more...
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TTM may also confer benefits to patients experiencing cardiac arrest in other clinical environments, [24] patients with hemorrhagic shock, [25] and patients with other forms of severe brain injury. [26, 27, 28, 29] Currently, at least 19 clinical trials are underway and focus principally on ROSC, traumatic brain injury, stroke, neonatal hypoxic-ischemic encephalopathy, and medical device safety. [30] Currently, no evidence supports using this modality for stroke. [31]

The process of selecting patients and initiating therapy is not complex. The ERC states that hypothermia is "safe and effective even if there is lack of experience." [32] The practice has been successfully applied in the academic tertiary care environment and in the community hospital setting, and it has been successfully implemented in the prehospital environment. [33, 34, 35, 36]

Implementation of hypothermia does require planning, education, and integration of multiple services within an institution. The basic framework for clinical protocols are well established, and institutions interested in establishing protocols may find a substantial amount of prior art in the literature (see hypothermia protocols).

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