How are Interleukin (IL) cardiac markers characterized and what do they indicate?

Updated: Jul 30, 2021
  • Author: Kamal (Komo) Gursahani, MD, MBA; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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IL-6 and IL-18 are produced by many different cell types, including macrophages that reside in atherosclerotic plaques and, once released, cause a proinflammatory response. High IL-6 levels in coronary artery disease, symptomatic or asymptomatic, has been associated with a higher risk of death. Unfortunately, like many other inflammatory markers, it is elevated in several disease states, which greatly limits its specificity. [82] High serum levels of IL-18 are associated with an increased risk of developing cardiovascular disease in the general population, increased mortality in heart failure patients, and development of CHF and acute MI (AMI) in patients with ACS. [83]

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