What is the role of thrombolytic therapy during cardiac arrest?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Several case reports, retrospective analyses, and prospective studies have shown favorable results for the use of thrombolytic therapy in cardiac arrest. [69, 70, 71] In most case reports, acute pulmonary embolism (PE) or acute myocardial infarction (AMI) was the suspected cause.

Active cardiopulmonary resuscitation (CPR) is clearly not a contraindication for thrombolytic therapy. At present, however, there is insufficient evidence to support routine use of thrombolytic drugs during cardiac arrest. Nevertheless, the clinician may consider it on a case-by-case basis

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