What are standard regimens for thrombolytic therapy in peripheral arterial disease (PAD)?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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The standard regimen for reteplase in PAD consists of 0.5 U/hr by intra-arterial infusion.

The standard regimen for alteplase consists of 0.05-0.1 mg/kg/hr intra-arterially. The high-dose regimen consists of three doses of 5 mg over 30 minutes followed by 3.5 mg/hr for up to 4 hours.

The regimen for urokinase consists of 4000 U/min intra-arterially until initial recanalization, then 1000-2000 U/min intra-arterially until complete lysis.

The regimen for streptokinase consists of 5000-10,000 U/hr intra-arterially.

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