What are the contraindications to thrombolytic therapy in patients with peripheral arterial disease (PAD)?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Patients with limb-threatening ischemia are not candidates for local fibrinolysis, which usually takes between 6 and 72 hours to achieve clot lysis. These patients require emergency embolectomy. CDT is reserved for patients with non–life-threatening limb ischemia due to in-situ thrombosis of less than 14 days’ duration. [62, 63] Consider that patients with thrombosis of more than 30 days’ duration are not likely to respond to local fibrinolysis.

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